The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may end in an increase in methadone plasma concentrations, which could lead to perhaps fatal respiratory melancholy. On top of that, discontinuation of concomitantly used cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may additionally end in an increase… Read More